Article
Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.
European journal of medicinal chemistry - 1 Sept 2010
Chenna Bala Chandra, King Jason R, Shinkre Bidhan A, Glover Amanda L, Lucius Aaron L, Velu Sadanandan E
Abstract excerpt
Synthetic methods have been developed for lead Sortase A inhibitors identified from previous studies. Several derivatives of the lead inhibitor were synthesized to derive preliminary structure activity relationships (SAR). Different regions of the lead inhibitor that are critical for the enzyme activity have been determined by systematic SAR studies. The E stereochemistry of the lead compound was found to be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.