Article

Shared trans-ancestry architecture of HLA-mediated disease risk in the <i>All of Us</i> Research Program

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> The human leukocyte antigen (HLA) region is the strongest genetic contributor to many immune-mediated diseases, yet whether HLA architecture is shared across ancestries remains unclear. We analyzed high-resolution HLA variation in 390,823 participants from the All of Us Research Program spanning six genetic ancestry groups, including 262,915 with linked electronic health records. Using whole-ge...

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Literature Corpus work: f286dcf9-e069-5049-b440-f123d8bb985b
DOI: 10.64898/2026.06.26.26356709

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