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Article

Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Norman Jane E, Cunningham Margaret R, Jones Matthew L, Walker Mary E, Westbury Sarah K, Sessions Richard B, Mundell Stuart J, Mumford Andrew D

Abstract excerpt

OBJECTIVE: Protease-activated receptor 4 (PAR4) is a key regulator of platelet reactivity and is encoded by F2RL3, which has abundant rare missense variants. We aimed to provide proof of principle that rare F2LR3 variants potentially affect platelet reactivity and responsiveness to PAR1 antagonist drugs and to explore underlying molecular mechanisms. APPROACH AND RESULTS: We identified 6 rare F2RL3 missense...

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PMID: 26966273
DOI: 10.1161/ATVBAHA.115.307102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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