Article

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

2021-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in, or deficiency of, FMRP is responsible for the Fragile X syndrome (FXS), the most common cause for inherited intellectual disability. FMRP is a nucleocytoplasmic protein, primarily characterized as a translation repressor with poorly understood nuclear function(s). We recently uncovered a genome protective role of FMRP. We reported that FXS patient-derived cells lacking FMRP sustain...

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Literature Corpus work: 18c4a4e5-dad4-5079-a283-b5c075088e00
DOI: 10.1101/2021.04.21.440759

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