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Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions

4 Oct 2018

Abstract excerpt

Tauopathies such as Alzheimer's Disease (AD) are neurodegenerative disorders for which there is presently no cure. They are named after the abnormal oligomerization/aggregation of the neuronal microtubule-associated Tau protein. Besides its role as a microtubule-associated protein, a DNA-binding capacity and a nuclear localization for Tau protein has been described in neurons. While questioning the potential role...

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PMID: 30321409
DOI: 10.1093/nar/gky929

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