Article

Tau Protein Modulates an Epigenetic Mechanism of Cellular Senescence

2023-06-05

Abstract excerpt

Progressive Tau deposition in neurofibrillary tangles and neuropil threads is the hallmark of tauopathies, a disorder group that includes Alzheimer’s disease. Since Tau is a microtubule-associated protein, a prevalent concept to explain the pathogenesis of tauopathies is that abnormal Tau modification contributes to dissociation from microtubules, assembly into multimeric β-sheets, proteotoxicity, neuronal dysfunc...

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Literature Corpus work: a4b9b0e8-6a00-52c8-bb2f-ff99041034ca
DOI: 10.1101/2023.06.05.543662

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