Chronic low dose UV exposure and p53 mutation: tilting the odds in early epidermal preneoplasia?

Abstract excerpt

PURPOSE: This review addresses how mutation of the TP53 gene (p53) and ultraviolet light alter the behavior of normal progenitor cells in early epidermal preneoplasia. CONCLUSIONS: Cancer is thought to evolve from single mutant cells, which expand into clones and ultimately into tumors. While the mutations in malignant lesions have been studied intensively, less is known about the earliest stages of preneoplasia,...

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