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Article

Structure and evolution of double minutes in diagnosis and relapse brain tumors

28 Sept 2018

Abstract excerpt

Double minute chromosomes are extrachromosomal circular DNA fragments frequently found in brain tumors. To understand their evolution, we characterized the double minutes in paired diagnosis and relapse tumors from a pediatric high-grade glioma and four adult glioblastoma patients. We determined the full structures of the major double minutes using a novel approach combining multiple types of supporting genomic...

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PMID: 30267146
DOI: 10.1007/s00401-018-1912-1

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