Article
Extrachromosomal driver mutations in glioblastoma and low-grade glioma.
Nature communications - 4 Dec 2014
Nikolaev Sergey, Santoni Federico, Garieri Marco, Makrythanasis Periklis, Falconnet Emilie, Guipponi Michel, Vannier Anne, Radovanovic Ivan, Bena Frederique, Forestier Françoise, Schaller Karl, Dutoit Valerie, Clement-Schatlo Virginie, Dietrich Pierre-Yves, Antonarakis Stylianos E
Abstract excerpt
Alteration of the number of copies of double minutes (DMs) with oncogenic EGFR mutations in response to tyrosine kinase inhibitors is a novel adaptive mechanism of glioblastoma. Here we provide evidence that such mutations in DMs, called here amplification-linked extrachromosomal mutations (ALEMs), originate extrachromosomally and could therefore be completely eliminated from the cancer cells. By exome sequencing...
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