Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.

doi:10.1093/annonc/mdv127

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Article

Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2015

Favero F, McGranahan N, Salm M, Birkbak N J, Sanborn J Z, Benz S C, Becq J, Peden J F, Kingsbury Z, Grocok R J, Humphray S, Bentley D, Spencer-Dene B, Gutteridge A, Brada M, Roger S, Dietrich P-Y, Forshew T, Gerlinger M, Rowan A, Stamp G, Eklund A C, Szallasi Z, Swanton C

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine approaches. METHODS: We describe a 35-year-old female patient with recurrent GBM following surgical removal of the...

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Identifiers

PMID: 25732040
DOI: 10.1093/annonc/mdv127
PMCID: PMC4405282

Genes

IDH1
KIT
PDGFRA
CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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