A sequence-based survey of the complex structural organization of tumor genomes.

doi:10.1186/gb-2008-9-3-r59

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Article

A sequence-based survey of the complex structural organization of tumor genomes.

Genome biology - 1 Jan 2008

Raphael Benjamin J, Volik Stanislav, Yu Peng, Wu Chunxiao, Huang Guiqing, Linardopoulou Elena V, Trask Barbara J, Waldman Frederic, Costello Joseph, Pienta Kenneth J, Mills Gordon B, Bajsarowicz Krystyna, Kobayashi Yasuko, Sridharan Shivaranjani, Paris Pamela L, Tao Quanzhou, Aerni Sarah J, Brown Raymond P, Bashir Ali, Gray Joe W, Cheng Jan-Fang, de Jong Pieter, Nefedov Mikhail, Ried Thomas, Padilla-Nash Hesed M, Collins Colin C

Abstract excerpt

BACKGROUND: The genomes of many epithelial tumors exhibit extensive chromosomal rearrangements. All classes of genome rearrangements can be identified using end sequencing profiling, which relies on paired-end sequencing of cloned tumor genomes. RESULTS: In the present study brain, breast, ovary, and prostate tumors, along with three breast cancer cell lines, were surveyed using end sequencing profiling, yielding...

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Identifiers

PMID: 18364049
DOI: 10.1186/gb-2008-9-3-r59
PMCID: PMC2397511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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