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Molecular structure and evolution mechanism of two populations of double minutes in human colorectal cancer cells

30 Oct 2020

Abstract excerpt

Gene amplification chiefly manifests as homogeneously stained regions (HSRs) or double minutes (DMs) in cytogenetically and extrachromosomal DNA (ecDNA) in molecular genetics. Evidence suggests that gene amplification is becoming a hotspot for cancer research, which may be a new treatment strategy for cancer. DMs usually carry oncogenes or chemoresistant genes that are associated with cancer progression,...

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PMID: 33124133
DOI: 10.1111/jcmm.16035

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