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Article

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

BMJ (Clinical research ed.) - 24 Apr 2017

Benn Marianne, Nordestgaard Børge G, Frikke-Schmidt Ruth, Tybjærg-Hansen Anne

Abstract excerpt

Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is associated with a high risk of Alzheimer's disease, vascular dementia, any dementia, and Parkinson's disease in the general population.Design Mendelian...

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Source

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Identifiers

PMID: 28438747
DOI: 10.1136/bmj.j1648
PMCID: PMC5421439

Genes

HMGCR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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