Article
Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity.
Genome biology - 11 Sept 2018
Geeleher Paul, Nath Aritro, Wang Fan, Zhang Zhenyu, Barbeira Alvaro N, Fessler Jessica, Grossman Robert L, Seoighe Cathal, Stephanie Huang R
Abstract excerpt
Expression quantitative trait loci (eQTLs) identified using tumor gene expression data could affect gene expression in cancer cells, tumor-associated normal cells, or both. Here, we have demonstrated a method to identify eQTLs affecting expression in cancer cells by modeling the statistical interaction between genotype and tumor purity. Only one third of breast cancer risk variants, identified as eQTLs from a...
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