Article

Development and validation of a gene expression score to account for tumour purity and improve prognostication in breast cancer

2024-02-27

Abstract excerpt

The prevalence of malignant cells in clinical specimens, or tumour purity, is affected by both intrinsic biological factors and extrinsic sampling bias. Molecular characterization of large clinical cohorts is typically performed on bulk samples; data analysis and interpretation can be biased by tumour purity variability. Transcription-based strategies to estimate tumour purity have been proposed, but no breast can...

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Literature Corpus work: b087de0a-df91-5462-b686-1a8e59fc3a16
DOI: 10.1101/2024.02.23.581701

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