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Inferring tumour purity and stromal and immune cell admixture from expression data

11 Oct 2013

Abstract excerpt

Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue and not only perturb the tumour signal in molecular studies but also have an important role in cancer biology. Here we describe ‘Estimation of STromal and Immune cells in MAlignant Tumours using Expression data’ (ESTIMATE)—a method that uses gene expression signatures to infer the fraction of stromal and immune cells in...

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PMID: 24113773
DOI: 10.1038/ncomms3612

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