Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples.

Abstract excerpt

Allele-specific expression (ASE) of somatic mutations can be caused by cis-activation of the mutant allele or silencing of the wild-type allele and has been investigated by examining the enrichment of mutant allele in RNA relative to DNA. Here we show that this mutation-based approach can be confounded by gene expression differences in tumor and normal cells that coexist in most bulk tumor samples. We model...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to EGFR gene
• Share to Gene Expression Regulation, Neoplastic