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Article

Impact of Tumor Purity on Immune Gene Expression and Clustering Analyses across Multiple Cancer Types.

Cancer immunology research - 1 Jan 2018

Rhee Je-Keun, Jung Yu Chae, Kim Kyu Ryung, Yoo Jinseon, Kim Jeeyoon, Lee Yong-Jae, Ko Yoon Ho, Lee Han Hong, Cho Byoung Chul, Kim Tae-Min

Abstract excerpt

Surgical archives of tumor specimens are often impure. The presence of RNA transcripts from nontumor cells, such as immune and stromal cells, can impede analyses of cancer expression profiles. To systematically analyze the impact of tumor purity, the gene expression profiles and tumor purities were obtained for 7,794 tumor specimens across 21 tumor types (available in The Cancer Genome Atlas consortium). First,...

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PMID: 29141981
DOI: 10.1158/2326-6066.CIR-17-0201

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