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Article

All-FIT: allele-frequency-based imputation of tumor purity from high-depth sequencing data.

Bioinformatics (Oxford, England) - 1 Apr 2020

Loh Jui Wan, Guccione Caitlin, Di Clemente Frances, Riedlinger Gregory, Ganesan Shridar, Khiabanian Hossein

Abstract excerpt

SUMMARY: Clinical sequencing aims to identify somatic mutations in cancer cells for accurate diagnosis and treatment. However, most widely used clinical assays lack patient-matched control DNA and additional analysis is needed to distinguish somatic and unfiltered germline variants. Such computational analyses require accurate assessment of tumor cell content in individual specimens. Histological estimates often...

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PMID: 31750888
DOI: 10.1093/bioinformatics/btz865
PMCID: PMC7141867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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