The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

doi:10.1210/jc.2018-00791

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Article

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

The Journal of clinical endocrinology and metabolism - 1 Dec 2018

Gerst Felicia, Jaghutriz Benjamin A, Staiger Harald, Schulte Anke M, Lorza-Gil Estela, Kaiser Gabriele, Panse Madhura, Haug Sieglinde, Heni Martin, Schütz Monika, Stadion Mandy, Schürmann Annette, Marzetta Flavia, Ibberson Mark, Sipos Bence, Fend Falko, Fleming Thomas, Nawroth Peter P, Königsrainer Alfred, Nadalin Silvio, Wagner Silvia, Peter Andreas, Fritsche Andreas, Richter Daniela, Solimena Michele, Häring Hans-Ulrich, Ullrich Susanne, Wagner Robert

Abstract excerpt

Context: Reduced β-cell mass, impaired islet function, and dedifferentiation are considered causal to development of hyperglycemia and type 2 diabetes. In human cohort studies, changes of islet cell-specific expression patterns have been associated with diabetes but not directly with in vivo insulin secretion. Objective: This study investigates alterations of islet gene expression and corresponding gene variants...

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Identifiers

PMID: 30202879
DOI: 10.1210/jc.2018-00791
PMCID: PMC6915830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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