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Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

20 Jul 2011

Abstract excerpt

OBJECTIVE: Gene expression alterations, especially in target tissues of insulin, have been associated with type 2 diabetes (T2D). In this study, we examined if genes involved in oxidative phosphorylation (OXPHOS) show differential gene expression and DNA methylation in pancreatic islets from patients with T2D compared with non-diabetic donors. DESIGN AND METHODS: Gene expression was analyzed in human pancreatic...

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PMID: 21775499
DOI: 10.1530/eje-11-0282

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