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Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia

8 Dec 2014

Abstract excerpt

Normal glucose homeostasis is characterized by appropriate insulin secretion and low HbA1c. Gene expression signatures associated with these two phenotypes could be essential for islet function and pathophysiology of type 2 diabetes (T2D). Herein, we employed a novel approach to identify candidate genes involved in T2D by correlating islet microarray gene expression data (78 donors) with insulin secretion and...

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PMID: 25489054
DOI: 10.1093/hmg/ddu610

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