Heterogeneous endocrine cell composition defines human islet functional phenotypes.

doi:10.1038/s41467-026-70689-5

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Article

Heterogeneous endocrine cell composition defines human islet functional phenotypes.

Nature communications - 12 May 2026

Evans-Molina Carmella, Pettway Yasminye D, Saunders Diane C, Sharp Seth A, Bate Thomas Sr, Sun Han, Durai Heather, Mei Shaojun, Coldren Anastasia, Davis Corey, Reihsmann Conrad V, Hopkirk Alexander L, Taylor Jay, Bradley Amber, Aramandla Radhika, Poffenberger Greg, Eskaros Adel, Jenkins Regina, Shi Danni, Xu Ke, Kang Hakmook, Rajesh Varsha, Thaman Swaraj, Feng Fan, Cartailler Jean-Philippe, Powers Alvin C, Abraham Kristin, Gloyn Anna L, Niland Joyce C, Brissova Marcela

Abstract excerpt

Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers and enable the integration of multiple data types. Data from islets of the first 299 organ donors without diabetes analyzed using this pipeline highlights substantial...

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PMID: 42120367
DOI: 10.1038/s41467-026-70689-5
PMCID: PMC13168233

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