Article
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
PloS one - 5 Sept 2007
Staiger Harald, Machicao Fausto, Stefan Norbert, Tschritter Otto, Thamer Claus, Kantartzis Konstantinos, Schäfer Silke A, Kirchhoff Kerstin, Fritsche Andreas, Häring Hans-Ulrich
Abstract excerpt
BACKGROUND: Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion exhausts. Insulin resistance and/or beta-cell dysfunction result from the interaction of environmental factors (high-caloric diet and reduced physical activity) with a predisposing polygenic background. Very recently, genetic variations within four novel genetic loci (SLC30A8, HHEX, EXT2, and LOC387761) were reported...
Topics
- Adolescent
- Adult
- Aged
- Body Composition
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Glucose Tolerance Test
- Humans
- Islets of Langerhans
- Middle Aged
- Polymorphism, Genetic
- Young Adult