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Article

Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.

PloS one - 10 Jun 2010

Kirkpatrick Clare L, Marchetti Piero, Purrello Francesco, Piro Salvatore, Bugliani Marco, Bosco Domenico, de Koning Eelco J P, Engelse Marten A, Kerr-Conte Julie, Pattou François, Wollheim Claes B

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified susceptibility genes for development of type 2 diabetes. We aimed to examine whether a subset of these (comprising FTO, IDE, KCNJ11, PPARG and TCF7L2) were transcriptionally restricted to or enriched in human beta cells by sorting islet cells into alpha and beta - specific fractions. We also aimed to correlate expression of these transcripts in both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20548773
DOI: 10.1371/journal.pone.0011053
PMCID: PMC2883550

Genes

KCNJ11
FTO
IDE
PPARG

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