Article
Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.
PLoS genetics - 1 Sept 2018
Richard Arianne C, Peters James E, Savinykh Natalia, Lee James C, Hawley Eric T, Meylan Françoise, Siegel Richard M, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier. Genome-wide association studies have identified over 200 genetic loci associated with risk for IBD, but the functional mechanisms of most of these genetic variants remain unknown. Polymorphisms at the TNFSF15 locus, which encodes the TNF superfamily cytokine...
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