Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014

Hedl Matija, Abraham Clara

Abstract excerpt

Inflammatory diseases are characterized by dysregulated cytokine production. Altered functions for most risk loci, including the inflammatory bowel disease and leprosy-associated tumor necrosis factor ligand superfamily member 15 (TNFSF15) region, are unclear. Regulation of pattern-recognition-receptor (PRR)-induced signaling and cytokines is crucial for immune homeostasis; TNFSF15:death receptor 3 (DR3)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAM17 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 8

Share to Mycobacterium

Share to Myeloid Cells

Share to Nod2 Signaling Adaptor Protein

Share to Receptors, Pattern Recognition

Share to Tissue Inhibitor of Metalloproteinase-3

Source

Open in PubMed Open full text

Identifiers

PMID: 25197060
DOI: 10.1073/pnas.1404178111
PMCID: PMC4169936

Genes

TNFSF15
FADD
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.PMID 25197060Read ↗

TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants.Semantic proximity Read ↗

Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.Semantic proximity Read ↗

IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Semantic proximity Read ↗

Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.Semantic proximity Read ↗

The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.Semantic proximity Read ↗

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Semantic proximity Read ↗

Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.Semantic proximity Read ↗

TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.Semantic proximity Read ↗

Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population.Semantic proximity Read ↗

Association of TNFSF15 with Crohn's disease in Koreans.Semantic proximity Read ↗

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.