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Article

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

PloS one - 1 Jan 2009

Michelsen Kathrin S, Thomas Lisa S, Taylor Kent D, Yu Qi T, Mei Ling, Landers Carol J, Derkowski Carrie, McGovern Dermot P B, Rotter Jerome I, Targan Stephan R

Abstract excerpt

BACKGROUND: The recently identified member of the TNF superfamily TL1A (TNFSF15) increases IFN-gamma production by T cells in peripheral and mucosal CCR9+ T cells. TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). TL1A gene haplotypes increase CD susceptibility in Japanese, European, and US cohorts. METHODOLOGY AND PRINCIPAL FINDINGS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19262684
DOI: 10.1371/journal.pone.0004719
PMCID: PMC2648040

Genes

TNFSF15
CCR9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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