Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.

Gastroenterology - 1 Jul 2017

Gonsky Rivkah, Fleshner Phillip, Deem Richard L, Biener-Ramanujan Eva, Li Dalin, Potdar Alka A, Bilsborough Janine, Yang Shaohong, McGovern Dermot P B, Targan Stephan R

Abstract excerpt

BACKGROUND & AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) have been associated with risk for inflammatory bowel disease (IBD). TL1A affects expression of multiple cytokines to promote mucosal inflammation. Little is known about the TL1A-response pathways that regulate cytokine expression. We investigated T-cell gene expression patterns to determine the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Aggregation
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Adhesion Molecule-1

Share to Interferon-gamma

Share to Intestinal Mucosa

Share to Lymphocyte Function-Associated Antigen-1

Share to Proto-Oncogene Proteins c-ets

Share to Ribonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 28400196
DOI: 10.1053/j.gastro.2017.04.002
PMCID: PMC5484733

Genes

RNASET2
IFNG
CD4
ICAM1
TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.PMID 28400196Read ↗

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells.Semantic proximity Read ↗

TL1A-activated T cells remodel the rectal mucosa in Crohn’s disease patients with perianal fistulizing diseaseSemantic proximity Read ↗

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants.Semantic proximity Read ↗

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.Semantic proximity Read ↗

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.Semantic proximity Read ↗

Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissuesSemantic proximity Read ↗

IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.Semantic proximity Read ↗

Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population.Semantic proximity Read ↗

Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes.Semantic proximity Read ↗

Association of TNFSF15 polymorphism with irritable bowel syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.