Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.

doi:10.1038/srep31429

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Article

Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.

Scientific reports - 10 Aug 2016

Sun Yonghu, Irwanto Astrid, Toyo-Oka Licht, Hong Myunghee, Liu Hong, Andiappan Anand Kumar, Choi Hyunchul, Hitomi Yuki, Yu Gongqi, Yu Yongxiang, Bao Fangfang, Wang Chuan, Fu Xian, Yue Zhenhua, Wang Honglei, Zhang Huimin, Kawashima Minae, Kojima Kaname, Nagasaki Masao, Nakamura Minoru, Yang Suk-Kyun, Ye Byong Duk, Denise Yosua, Rotzschke Olaf, Song Kyuyoung, Tokunaga Katsushi, Zhang Furen, Liu Jianjun

Abstract excerpt

Genetic polymorphism within the 9q32 locus is linked with increased risk of several diseases, including Crohn's disease (CD), primary biliary cholangitis (PBC) and leprosy. The most likely disease-causing gene within 9q32 is TNFSF15, which encodes the pro-inflammatory cytokine TNF super-family member 15, but it was unknown whether these disparate diseases were associated with the same genetic variance in 9q32,...

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PMID: 27507062
DOI: 10.1038/srep31429
PMCID: PMC4979016

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TNFSF15
TNF

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