Article
Association of TNFSF15 polymorphism with irritable bowel syndrome.
Gut - 1 Dec 2011
Zucchelli Marco, Camilleri Michael, Andreasson Anna Nixon, Bresso Francesca, Dlugosz Aldona, Halfvarson Jonas, Törkvist Leif, Schmidt Peter T, Karling Pontus, Ohlsson Bodil, Duerr Richard H, Simren Magnus, Lindberg Greger, Agreus Lars, Carlson Paula, Zinsmeister Alan R, D'Amato Mauro
Abstract excerpt
BACKGROUND: Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide. Although a genetic component is suspected, unambiguous susceptibility genes have so far not been identified. This study tested the hypothesis that genes contributing to epithelial barrier integrity, control of mucosal immune responses and interactions with bacteria...
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