Article
Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia.
Brain pathology (Zurich, Switzerland) - 1 Jan 2019
Rodriguez Fausto J, Brosnan-Cashman Jacqueline A, Allen Sariah J, Vizcaino M Adelita, Giannini Caterina, Camelo-Piragua Sandra, Webb Milad, Matsushita Marcus, Wadhwani Nitin, Tabbarah Abeer, Hamideh Dima, Jiang Liqun, Chen Liam, Arvanitis Leonidas D, Alnajar Hussein H, Barber John R, Rodríguez-Velasco Alicia, Orr Brent, Heaphy Christopher M
Abstract excerpt
Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma (PA) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains unclear. Fifty-seven resections from 36 patients (23 M, 13 F, mean age 32 years, range 3-75) were included. A clinical diagnosis of NF1 was present in 8 (22%). Alternative lengthening of telomeres...
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