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The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population

1 Nov 2019

Abstract excerpt

Abstract Pilocytic astrocytoma (PA) is the most common pediatric glioma, arising from a single driver MAPK pathway alteration. Classified as a grade I tumor according to the 2016 WHO classification, prognosis is excellent with a 10-year survival rate > 95% after surgery. However, rare cases present with anaplastic features, including an unexpected high mitotic/proliferative index, thus posing a diagnostic and...

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PMID: 31677015
DOI: 10.1007/s00401-019-02088-8

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