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Article

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.

Acta neuropathologica - 1 Mar 2011

Rodriguez Erika F, Scheithauer Bernd W, Giannini Caterina, Rynearson Amanda, Cen Ling, Hoesley Bridget, Gilmer-Flynn Heather, Sarkaria Jann N, Jenkins Sarah, Long Jin, Rodriguez Fausto J

Abstract excerpt

Pilocytic astrocytomas (PA) are well-differentiated gliomas having a favorable prognosis when compared with other diffuse or infiltrative astrocytomas. Molecular genetic abnormalities and activation of signaling pathways associated with clinically aggressive PA and histologically anaplastic PA ha...

Read the complete abstract on PubMed

Topics

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Share to Astrocytoma
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Mitogen-Activated Protein Kinase Kinases

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 21113787
DOI: 10.1007/s00401-010-0784-9
PMCID: PMC3417062

Genes

BRAF
PTEN
EGFR
IDH1
PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21113787-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.PMID 21113787Read ↗

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V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior.Semantic proximity Read ↗

Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region OriginSemantic proximity Read ↗

The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric populationSemantic proximity Read ↗

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The morphologic and molecular characteristics of pilocytic astrocytomas and the role of MAPK pathway: what does not kill you makes you stronger.Semantic proximity Read ↗

The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features.Semantic proximity Read ↗

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