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Adult pilocytic astrocytoma in the molecular era: a comprehensive review

15 Jan 2021

Abstract excerpt

Adult pilocytic astrocytoma (PA) is less prevalent than pediatric PA and is associated with a worse prognosis. In a literature review, we found that 88.3% of the molecular alterations in adult PA are associated with MAPK pathway dysregulation. The most common alterations are fusions of BRAF. Understanding of the mechanisms underlying this pathway has evolved substantially, heralding advancements in specific...

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PMID: 33448230
DOI: 10.2217/cns-2020-0027

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