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Article

Diagnostics for Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects.

American journal of epidemiology - 1 Dec 2018

Dai James Y, Peters Ulrike, Wang Xiaoyu, Kocarnik Jonathan, Chang-Claude Jenny, Slattery Martha L, Chan Andrew, Lemire Mathieu, Berndt Sonja I, Casey Graham, Song Mingyang, Jenkins Mark A, Brenner Hermann, Thrift Aaron P, White Emily, Hsu Li

Abstract excerpt

Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method evaluates whether there is evidence of bias-generating pleiotropy among a set of candidate genetic instrumental variables. In this article, we propose a statistical method-global and individual tests for direct effects (GLIDE)-for systematically evaluating pleiotropy among the set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30188971
DOI: 10.1093/aje/kwy177
PMCID: PMC6269243

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