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Article

An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics.

Bioinformatics (Oxford, England) - 16 Jun 2021

Zhu Xiaofeng, Li Xiaoyin, Xu Rong, Wang Tao

Abstract excerpt

MOTIVATION: The overall association evidence of a genetic variant with multiple traits can be evaluated by cross-phenotype association analysis using summary statistics from genome-wide association studies. Further dissecting the association pathways from a variant to multiple traits is important to understand the biological causal relationships among complex traits. RESULTS: Here, we introduce a flexible and...

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Share to Causality
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 33226062
DOI: 10.1093/bioinformatics/btaa985
PMCID: PMC8208738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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