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Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?

American journal of epidemiology - 1 Dec 2018

Bowden Jack, Hemani Gibran, Davey Smith George

Abstract excerpt

Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approaches for MR analysis. The recently proposed "global and individual tests for direct effects" (GLIDE) approach fits into...

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PMID: 30188969
DOI: 10.1093/aje/kwy185
PMCID: PMC6269239

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