Article
Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Aug 2005
Anderson Gregory J, Frazer David M, McKie Andrew T, Vulpe Christopher D, Smith Ann
Abstract excerpt
Our current state of knowledge of the mechanism and regulation of intestinal iron absorption has been critically dependent on the analysis of inherited disorders of iron homeostasis in both humans and other animal species. Mutations in DMT1 and Ireg1 have revealed that these molecules are major mediators of iron transport across the brush border and basolateral membranes of the enterocyte, respectively....
Topics
- Absorption
- Animals
- Biological Transport
- Cation Transport Proteins
- Disease Models, Animal
- Erythropoiesis
- Heme
- Hepatocytes
- Humans
- Intestinal Mucosa
- Iron
- Iron Metabolism Disorders
- Iron Overload
- Iron-Binding Proteins
- Macrophages
- Mice
- Models, Biological
- Mutation