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Article

Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene.

Gastroenterology - 1 Feb 2007

Gouya Laurent, Muzeau Francoise, Robreau Anne-Marie, Letteron Philippe, Couchi Eric, Lyoumi Saïd, Deybach Jean-Charles, Puy Herve, Fleming Robert, Demant Peter, Beaumont Carole, Grandchamp Bernard

Abstract excerpt

BACKGROUND & AIMS: Genetic hemochromatosis is one of the most common genetic disorders, with progressive tissue iron overload leading to severe clinical complications. In Northern European populations, genetic hemochromatosis is usually caused by homozygosity for the C282Y mutation in the HFE protein. However, penetrance of this mutation is incomplete, suggesting that other genetic and environmental factors...

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Source

Identifiers

PMID: 17258727
DOI: 10.1053/j.gastro.2006.11.024

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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