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Article

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Trinder Debbie, Olynyk John K, Sly William S, Morgan Evan H

Abstract excerpt

Hereditary hemochromatosis (HH) is a disorder of iron metabolism in which enhanced iron absorption of dietary iron causes increased iron accumulation in the liver, heart, and pancreas. Most individuals with HH are homozygous for a C282Y mutation in the HFE gene. The function of HFE protein is unk...

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Identifiers

PMID: 11943867
DOI: 10.1073/pnas.082112299
PMCID: PMC122820

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11943867-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.PMID 11943867Read ↗

Mechanisms of Iron Accumulation in Hereditary HemochromatosisSemantic proximity Read ↗

HFE gene knockout produces mouse model of hereditary hemochromatosisSemantic proximity Read ↗

Regulation of iron absorption in Hfe mutant mice.Semantic proximity Read ↗

Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability.Semantic proximity Read ↗

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1.Semantic proximity Read ↗

Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.Semantic proximity Read ↗

Hfe acts in hepatocytes to prevent hemochromatosis.Semantic proximity Read ↗

Physiology of iron transport and the hemochromatosis gene.Semantic proximity Read ↗

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload.Semantic proximity Read ↗

Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism.Semantic proximity Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

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