Article
Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype.
Blood - 5 Jun 2014
Zumerle Sara, Mathieu Jacques R R, Delga Stéphanie, Heinis Mylène, Viatte Lydie, Vaulont Sophie, Peyssonnaux Carole
Abstract excerpt
Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder. Hepcidin is produced mainly by the liver, but many cells and tissues express low levels of the hormone. To determine the...
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