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Article

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

Hepatology (Baltimore, Md.) - 1 Aug 2012

Delima Roheeth D, Chua Anita C G, Tirnitz-Parker Janina E E, Gan Eng K, Croft Kevin D, Graham Ross M, Olynyk John K, Trinder Debbie

Abstract excerpt

UNLABELLED: Mutations in hemochromatosis protein (HFE) or transferrin receptor 2 (TFR2) cause hereditary hemochromatosis (HH) by impeding production of the liver iron-regulatory hormone, hepcidin (HAMP). This study examined the effects of disruption of Hfe or Tfr2, either alone or together, on liver iron loading and injury in mouse models of HH. Iron status was determined in Hfe knockout (Hfe(-/-)), Tfr2 Y245X...

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Source

Identifiers

PMID: 22383097
DOI: 10.1002/hep.25689

Genes

HAMP
HFE
TFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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