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Article

The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.

PloS one - 1 Jan 2014

Fuqua Brie K, Lu Yan, Darshan Deepak, Frazer David M, Wilkins Sarah J, Wolkow Natalie, Bell Austin G, Hsu JoAnn, Yu Catherine C, Chen Huijun, Dunaief Joshua L, Anderson Gregory J, Vulpe Chris D

Abstract excerpt

Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood. Hephaestin is mutated in the sex-linked anemia mouse, resulting in iron deficiency. However, sex-linked anemia mice still retain some hephaestin ferroxidase activity. They survive, breed, and their anemia improves with age. To gain a better understanding of the role of hephaestin in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24896847
DOI: 10.1371/journal.pone.0098792
PMCID: PMC4045767

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