Article
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
17 Jul 2018
Abstract excerpt
Telomeres play crucial roles during tumorigenesis, inducing cellular senescence upon telomere shortening and extensive chromosome instability during telomere crisis. However, it has not been investigated if and how cellular transformation and oncogenic stress alter telomeric chromatin composition and function. Here, we transform human fibroblasts by consecutive transduction with vectors expressing hTERT, the SV40...
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