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Article

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

1 Dec 2012

Abstract excerpt

Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the nuclear volume. We discovered an unambiguous enrichment of telomeres at the nuclear periphery during postmitotic nuclear assembly, whereas telomeres were localized...

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PMID: 23260663
DOI: 10.1016/j.celrep.2012.11.019

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