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Article

Emerging roles of telomeric chromatin alterations in cancer

17 Jan 2019

Abstract excerpt

Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the specific complex named shelterin and a tight nucleosomal organization. Telomere shortening in duplicating somatic cells leads eventually to the destabilization of...

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Share to Epigenetics and DNA Methylation
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PMID: 30654820
DOI: 10.1186/s13046-019-1030-5

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