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Article

Chromatin Structure in Telomere Dynamics

1 Jan 2013

Abstract excerpt

The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence. In normal human somatic cells, characterized by telomere shortening with each cell division, telomere uncapping is a regulated...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 23471416
DOI: 10.3389/fonc.2013.00046

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