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Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape

31 Aug 2020

Abstract excerpt

Shigella flexneri invades host cells by entering within a bacteria-containing vacuole (BCV).In order to establish its niche in the host cytosol, the bacterium ruptures its BCV.Contacts between S. flexneri BCV and infection-associated macropinosomes (IAMs) formed in situ have been reported to enhance BCV disintegration.The mechanism underlying S. flexneri vacuolar escape remains however obscure.To decipher the...

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PMID: 32866204
DOI: 10.1371/journal.ppat.1008822

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