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Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in <i>Pseudomonas aeruginosa</i>

2022-09-14

Abstract excerpt

Pseudomonas aeruginosa is an important human pathogen that can cause severe wound and lung infections. It employs the type VI secretion system (H1-T6SS) as a molecular weapon to carry out a unique dueling response to deliver toxic effectors to neighboring sister cells or other microbes after sensing an external attack. However, the underlying mechanism for such dueling is not fully understood. Here, we examined th...

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Literature Corpus work
de273e9e-7f1d-514e-a8ab-c4889e814b03
DOI
10.1101/2022.09.14.507963
Open publication

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